Synthetically Lethal Biomimetic Nutri-Hijacker Hitchhikes and Reprograms KRAS Mutation-Driven Metabolic Addictions for Pancreatic Ductal Adenocarcinoma Treatment

The authors proposed a biomimetic “Nutri-hijacker” with “Trojan horse” design to induce synthetic lethality in KRAS-mutated malignant cells by hitchhiking and reprogramming the metabolic addictions.