Liver Lipophagy Ameliorates Nonalcoholic Steatohepatitis Through Extracellular Lipid Secretion

Researchers engineered a synthetic adaptor protein to induce lipophagy, combining a lipid droplet-targeting signal with an optimized LC3-interacting domain. Activating hepatocyte lipophagy in vivo strongly mitigated both steatosis and hepatitis in a diet-induced mouse nonalcoholic steatohepatitis model.