Design, Synthesis, and Docking Studies of Novel Pyrazole-Based Scaffolds and Their Evaluation As VEGFR2 Inhibitors in the Treatment of Prostate Cancer

A series of 3-phenyl-4-(2-substituted phenylhydrazono)-1H-pyrazol-5(4H)-ones were synthesized and investigated for their cytotoxicity against the PC-3 human cancer cell line, compared to Doxorubicin and Sorafenib as reference drugs.