Activation of GPR44 Decreases Severity of Myeloid Leukemia via Specific Targeting of Leukemia Initiating Stem Cells

Using a murine acute myeloid leukemia (AML) model, human AML cell lines, and patient samples, scientists showed that AML LICs were sensitive to endogenous and exogenous cyclopentenone prostaglandin-J, Δ12-PGJ2, and 15d-PGJ2, which were increased upon dietary selenium supplementation via the cyclooxygenase-hematopoietic PGD synthase pathway.