Switching Mechanism from AR to EGFR Signaling via 3-O-Sulfated Heparan Sulfate in Castration-Resistant Prostate Cancer

Using the human prostate cancer cell line C4-2, investigators found that epidermal growth factor (EGF)-activated EGFR–ERK1/2 signaling via 3-O-sulfated heparan sulfate produced by HS 3-O-sulfotransferase 1 is activated in C4-2 cells under hormone depletion.