Hyperglucagonaemia in Diabetes: Altered Amino Acid Metabolism Triggers mTORC1 Activation, Which Drives Glucagon Production

To study the role of mTORC1 in mediating hyperglucagonaemia in diabetes, researchers generated an inducible alpha cell-specific Rptor knockout in the Akita mouse model of diabetes, and tested the effects on glucose tolerance by IPGTT and on glucagon secretion.