Kynurenine Monooxygenase Regulates Inflammation during Critical Illness and Recovery in Experimental Acute Pancreatitis

Mice with elevated 3-hydroxykynurenine succumbed fatally earlier and more readily to experimental acute pancreatitis. Therapeutically, blockade with the highly selective kynurenine monooxygenase inhibitor GSK898 rescued the phenotype, reducing 3-hydroxykynurenine and protecting against critical illness and death.