Enhancement of the SESN2-SHP Cascade by Melatonin Ameliorates Hepatic Gluconeogenesis by Inhibiting the CRBN-BTG2-CREBH Signaling Pathway

Investigators explored a novel molecular mechanism by which the melatonin-induced sestrin2 (SESN2)-small heterodimer partner (SHP) signaling pathway protected against fasting- and diabetes-mediated hepatic glucose metabolism.