Multi-Level Functional Genomics Reveals Molecular and Cellular Oncogenicity of Patient-Based 3′ Untranslated Region Mutations

To determine the significance of 3′ untranslated region (3′ UTR) mutations in disease, investigators identified 3′ UTR somatic variants across 185 advanced prostate tumors, discovering 14,497 single-nucleotide mutations enriched in oncogenic pathways and 3′ UTR regulatory elements.