Nicardipine Is a Putative EED Inhibitor and Has High Selectivity and Potency against Chemoresistant Prostate Cancer in Preclinical Models

A phenotypic screen was performed to identify novel inhibitors of chemoresistant prostate cancer (PCa) cells. The mechanism of action of potential candidate(s) was investigated using in silico docking, and molecular and cellular assays in chemoresistant PCa cells.