Cooperative Activation of PDK1 and AKT by MAPK4 Enhances Cancer Growth and Resistance to Therapy

Using TNBC cell models, researchers demonstrated that mitogen-activated protein kinase 4 (MAPK4) could also enhance phosphoinositide-dependent protein kinase-1 (PDK1) protein synthesis, thus phosphorylate/activate PDK1 substrates beyond AKT.