Promyelocytic Leukemia Protein Regulates Angiogenesis and Epithelial–Mesenchymal Transition to Limit Metastasis in MDA-MB-231 Breast Cancer Cells

Investigators showed that promyelocytic leukemia protein (PML) knockdown in MDA-MB-231, but not MCF7, breast cancer cells, prolonged stem-cell-like survival, and increased cell proliferation and migration, which was in line with gene-enrichment results from their RNA sequencing analysis.