Alternative Splicing of CEACAM1 by Hypoxia-Inducible Factor–1α Enhances Tolerance to Hepatic Ischemia in Mice and Humans

Investigators studied how alternative splicing of Ceacam1 affected ischemia-reperfusion injury (IRI) in mouse and human livers. They found that the short cytoplasmic isoform Ceacam1-S increased during early acute and late resolution phases of warm IRI injury in mice.