Exposure of iPSC-Derived Human Microglia to Brain Substrates Enables the Generation and Manipulation of Diverse Transcriptional States In Vitro

Investigator developed a platform for modeling human microglia transcriptional states in vitro. They found that exposure of human stem-cell-differentiated microglia to synaptosomes, myelin debris, apoptotic neurons, or synthetic amyloid-beta fibrils generated transcriptional diversity that mapped to gene signatures identified in human brain microglia.