Circulating Extracellular Vesicles Derived from Tumor Endothelial Cells Hijack the Local and Systemic Anti-tumor Immune Response: Role of mTOR/G-CSF Pathway

Scientists demonstrated that circulating tumor-endothelial cells boost lung metastasis and angiogenesis. FACS and immunohistochemically analyses revealed a significant enrichment of Ly6G+/F4/80+/CD11b+ cells and Ly6G+/F4/80–/CD11b+ in the lung and in the spleen, while Ly6G+/F4/80–/CD11b+ in the bone marrow, indicating the occurrence of a systemic and local immune suppression.