Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S-Palmitoylated IRHOM2

The authors found that inactive rhomboid protein 2 (IRHOM2) was post-translationally S-palmitoylated at C476 in iRhom homology domain, which facilitated its cytomembrane translocation and stabilization.