Apatinib Induces Zebrafish Hepatotoxicity by Inhibiting Wnt Signaling and Accumulation of Oxidative Stress

Researchers used zebrafish to investigate the effects of apatinib on the development of embryos. Zebrafish exposed to 2.5, 5, and 10 μM apatinib showed adverse effects such as decreased liver area, pericardial oedema, slow yolk absorption, bladder atrophy, and body length shortening.