6-Methoxydihydrosanguinarine Exhibits Cytotoxicity and Sensitizes TRAIL-Induced Apoptosis of Hepatocellular Carcinoma Cells through ROS-Mediated Upregulation of DR5

The authors revealed the underlying mechanisms of 6-methoxydihydrosanguinarine (6-MS)-induced cytotoxicity in HCC cells and investigated whether 6-MS sensitized TNF-related apoptosis inducing ligand-induced apoptosis.