Target Delivery of a PD-1-TREM2 scFv by CAR-T Cells Enhances Anti-Tumor Efficacy in Colorectal Cancer

The authors found that the programmed death-1 (PD-1)-triggering-receptor-expressed on myeloid cells 2 (TREM2)-targeting single-chain variable fragment (scFv) inhibited the activation of the PD-1/PD-L1 pathway.