Anticancer Activities of DNA-Alkylating Pyrrole–Imidazole Polyamide Analogs Targeting RUNX Transcription Factors against p53-Mutated Pancreatic Cancer PANC-1 Cells

Investigators evaluated the anticancer effects of 1 and its analogs 2–4 against p53-mutated PANC-1 pancreatic cancer cells. They found that they possessed different DNA-alkylating properties in vitro.