A Bovine Milk-Derived Peptide Ameliorates Pancreatic β-Cell Dedifferentiation Through PI3K/Akt/FOXO1 Signaling in Type 2 Diabetes†

The lacto-ghrestatin derived nonapeptide, a bioactive peptide derived from lacto-ghrestatin in bovine milk with the sequence of LIVTQTMKG, was investigated to determine its effects on islet β cell dedifferentiation and associated mechanisms in type 2 diabetes mellitus.