Comparative Analysis of YAP/TEAD Inhibitors in 2D and 3D Cultures of Primary Human Hepatocytes Reveals a Novel Non-Canonical Mechanism of CYP Induction

Researchers tested the liability for cytochrome P450 (CYP) induction of a diverse set of yes-associated protein (YAP)/TEA domain transcription factor (TEAD) inhibitors with different modes of action and TEAD isoform selectivity profiles in monolayers and 3D spheroids of primary human hepatocytes.