Integrative Proteomics and N-glycoproteomics Reveal the Synergistic Anti-tumor Effects of Aspirin- and Gemcitabine-Based Chemotherapy on Pancreatic Cancer Cells

The authors found that the addition of aspirin enhanced the inhibitory effect of gemcitabine on the activity of PANC-1 and BxPC-3 cells. Quantitative N-glycoproteome, proteome, phosphorylation, and transcriptome data were obtained from integrated multi-omics analysis to evaluate the anti-tumor effects of aspirin and gemcitabine on pancreatic cancer cells.