ER Stress Induces Caspase-2-tBID-GSDME-Dependent Cell Death in Neurons Lytically Infected With Herpes Simplex Virus Type 2

Investigators reported that lytic herpes simplex virus type 2 infection of human neuron-like SH-SY5Y cells and primary human and murine brain cells leads to cell death mediated by gasdermin E (GSDME).