MKP1 Promotes Nonalcoholic Steatohepatitis by Suppressing AMPK Activity Through LKB1 Nuclear Retention

Researchers uncovered a mechanism of adenosine monophosphate-activated protein kinase expression in the nonalcoholic fatty liver disease to nonalcoholic steatohepatitis transition, which was mediated by a nuclear mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP1)/p38 MAPK-LKB1 axis that promoted hepatocyte death.