Pre-Clinical Validation of a Pan-Cancer CAR-T Cell Immunotherapy Targeting nfP2X7

Investigators presented a prototype -human CAR-T construct targeting nfP2X7 showing potential antigen-specific cytotoxicity against 12 solid cancer types. In xenograft mouse models of breast and prostate cancer, CAR-T cells targeting nfP2X7 exhibit robust anti-tumor efficacy.