Alternative Splicing of Its 5′ UTR Limits CD20 mRNA Translation and Enables Resistance to CD20-Directed Immunotherapies

Investigators showed that the MS4A1 gene encoding human CD20 also produces several mRNA isoforms with distinct 5′ untranslated regions. Four variants were detectable by RNA-seq in distinct stages of normal B cell differentiation and B lymphoid malignancies, with V1 and V3 being the most abundant by far.