Bone Marrow Fibrosis Is Associated with Non-Response to CD19 CAR T-cell Therapy in B-acute Lymphoblastic Leukemia

Scientists performed whole transcriptome analysis, reticulin fibrosis assessment, and CD3 T-cell infiltration on bone marrow core biopsies from pre- and post-CAR timepoints for 61 patients, as well as on a cohort of 54 primary B-acute lymphoblastic leukemia samples.