The Application of HER2 and CD47 CAR-Macrophage in Ovarian Cancer

Researchers investigated the therapeutic application of CAR-macrophages in ovarian cancer. They constructed novel CAR structures, which consisted of humanized anti-HER2 or CD47 scFv, CD8 hinge region, and transmembrane domains, as well as the 4-1BB and CD3ζ intracellular domains.