Newsletters

[Tempus AI, Inc.] Tempus AI, Inc. announced that the US FDA has granted approval for a tumor-only indication for its xT companion diagnostic next-generation sequencing platform.

[Cellular & Molecular Immunology] Researchers identified ubiquitin-specific peptidase 9X (USP9X) as a critical negative regulator of intestinal inflammation. USP9X expression is reduced in Ulceralative Colitis patients and inversely correlates with disease severity.

[Molecular Cancer Research] Scientists characterized the expression landscape of KLK2 and STEAP1 in metastatic CRPC and defined associated transcriptomic, genomic, and epigenomic features.

[Communications Biology] Researchers characterized the molecular composition of the tumor microenvironment of androgen-sensitive and CRPC by utilizing patient-derived xenograft models.

[Cell Death & Disease] Scientists utilized their established enzalutamide-resistant prostate cancer cell lines to reveal a vulnerability of these cancer cells to GPX4-targeted ferroptosis.

[Epigenomics] Scientists presented a perspective on how the spatial architecture of the epigenome, including 3D chromatin structure and dynamics, orchestrates dysregulation of transcription factor networks that help to drive disease progression in androgen-driven prostate cancer.

[Discover Oncology] The authors review recent advances in prostate cancer biomarkers, encompassing genetic, proteomic, liquid biopsy, and imaging-based approaches. Genetic mutations inform disease prognosis and therapy selection, while proteomic biomarkers elucidate molecular mechanisms and therapeutic targets.

[28bio (BioSpace)] 28bio announced CNS-3D Inflammatory Organoids, designed to evaluate efficacy of anti-inflammatory drugs by quantifying their ability to reduce inflammatory injury, preserve tissue health, and restore neuronal network activity.

[Cell Stem Cell] Researchers generated human amygdala-like telencephalic organoids (hATOs) that recapitulated cellular composition, region-specific development, and key features of the amygdala. They highlight the potential of hATOs to understand molecular features of affective circuitry underlying emotion.

[Developmental Cell] Scientists established a stable biobank of 16 long-term cultured appendiceal adenocarcinoma (AC) patient-derived tumor organoids. Single-cell profiling reveals dedifferentiation from differentiated states in primary AC into intestinal stem cell and fetal progenitor states in AC-peritoneal carcinomatosis, with upregulation of oncogenic signaling pathways.

[Ecotoxicology and Environmental Safety] The authors established a hPSC-derived airway organoid platform and systematically compared the toxicological profiles of two heated tobacco product aerosols.

[Cell Biomaterials] The application of skin organoid models in the biomedical field is of great significance for the treatment of rare diseases such as genetic diseases, the tissue repair of large wounds caused by scleroderma or frostbite, and patient-specific drug screening.