Downregulation of NHE1 Expression Attenuates Apoptosis of Primary Hippocampal Neurons of an Epilepsy Model through the Calpain-1 Pathway

Primary hippocampal neurons were cultured in an Mg2+-free medium to establish an epilepsy cell model. Designed shNHE1 lentivirus was used to silence Na(+)/H(+) exchanger isoform 1 (NHE1) level in primary neurons.