Interaction between Estrogen Receptor-α and PNPLA3 p.I148M Variant Drives Fatty Liver Disease Susceptibility in Women

Scientists showed that there was a specific multiplicative interaction between female sex and PNPLA3 p.I148M in determining fatty liver disease in at-risk individuals (steatosis and fibrosis, and advanced fibrosis/hepatocellular carcinoma) and in the general population.