Newsletters

[Kincell Bio] Kincell Bio announced a new collaboration with RegCell, a biotechnology company developing first‑in‑class immune tolerance platform based on epigenetically reprogrammed regulatory T cells.

[Cell Research] Using long-term live-cell imaging to follow the fates of single ESCs, scientists showed that ESC lineage renewal is achieved through sporadic entry into a state characterized by the expression of two-cell embryo-specific markers.

[Genome Research] Investigators systematically studied microRNA alternative functions in mouse embryonic stem cells by genetically deleting Drosha, leading to global loss of microRNAs.

[EMBO Reports] Scientists showed that NANOG partners with TBX3 and the PRC2 complex to maintain ESC identity by silencing primitive endoderm genes through newly identified distal enhancers.

[Scientific Reports] By simulating the in vivo developmental process of γδT cells, investigators established stroma cell-free differentiation approach with three stages under 3D suspension culture in conjunction with using hypoxic conditions.

[Biochemical and Biophysical Research Communications] Scientists generated hESCs that stably express doxycycline inducible BAP1 shRNAs. In the undifferentiated cells, doxycycline addition induced BAP1 downregulation, without any effect on the undifferentiated state.

[In Vitro Cellular & Developmental Biology - Animal] Researchers provided an efficient approach for monitoring retinal progenitor cells (RPCs) to optimize in vitro maintenance conditions. This was designed by introducing a stable line of hESCs expressing EGFP reporter driven by the human RAX promoter as a key biomarker of RPCs.

[Lasers in Medical Science] Scientists investigated the effects of 810-nm photobiomodulation on the proliferation and cardiac differentiation of hiPSC, utilizing a custom-made LED device.

[Stem Cell Research & Therapy] Researchers highlighted how diverse CRISPR modalities—including knock-out, knock-in, CRISPRa/i, and genome-scale screening—have been applied to dissect gene function, model disease progression, and guide therapeutic development using iPSC- and organoid-based systems.

[Nature] Researchers uncovered a previously unrecognized regulatory axis by which cell surface ribonucleoproteins negatively modulate heparan sulfate-mediated signalling in the context of angiogenesis driven by VEGF-A.

[Science Translational Medicine] Investigators found that the developmental transcription factor sine oculis homeobox 1 (Six1) was increased in patients with pulmonary hypertension (PH) and that deleting Six1 in endothelial cells improved pathology in a mouse model of PH.

[Nature Communications] Scientists demonstrated that tumor endothelial cells (TECs) highly express actin-binding genes, with PDZ and LIM domain 5 (PDLIM5), a cytoskeletal protein, significantly upregulated in TECs and correlated with poor patient survival.