Characterization and AAV-Mediated CRB Gene Augmentation in Human Derived CRB1^KO and CRB1^KOCRB2^+/- Retinal Organoids

CRB1KO and CRB1KOCRB2+/- differentiation day 210 retinal organoids showed a significant decrease in the number of photoreceptor nuclei in a row and a significant increase in the number of photoreceptor cell nuclei above the outer limiting membrane.