Conditional Knockout of PDK1 in Osteoclasts Suppressed Osteoclastogenesis and Ameliorated Prostate Cancer-Induced Osteolysis in Murine Model

Deletion of 3-phosphoinositide-dependent protein kinase-1 (PDK1) in osteoclasts ameliorated osteolysis and reduced bone resorption markers in the murine model of prostate cancer-induced osteolysis.