Coinhibition of Topoisomerase 1 and BRD4-Mediated Pause Release Selectively Kills Pancreatic Cancer via Readthrough Transcription

Using patient-derived xenografts of KRAS- and MYC-driven pancreatic carcinoma, scientists showed that coinhibition of topoisomerase 1 and bromodomain-containing protein 4 (BRD4) synergistically induced tumor regression by targeting promoter pause release.