Free Interleukin-18 Is Elevated in CD22 CAR T-cell–Associated Hemophagocytic Lymphohistiocytosis–Like Toxicities

After a comprehensive clinical characterization and cytokine profiling of patients enrolled in a Phase I clinical trial evaluating CD22 CAR T cells for B cell malignancies, investigators further analyzed samples from 10 patients with CRS for total IL-18, free IL-18, and IL-18BP, comparing results from those with and without hemophagocytic lymphohistiocytosis-like toxicities