Dynamic Reversibility of α-Synuclein Serine-129 Phosphorylation Is Impaired in Synucleinopathy Models

Researchers showed that Parkinson’s disease-linked missense mutations in SNCA impacted activity-dependent pS129. Under basal conditions, cytosol-enriched A30P, H50Q, and G51D mutant forms of α-synuclein exhibited reduced pS129 levels in rat primary cortical neurons.