Translational Development of a Novel BAFF-R CAR-T Therapy Targeting B Cell Lymphoid Malignancies

The authors presented the development of a novel CAR-T cell therapy targeting B-cell activating factor receptor, a key regulator of B-cell proliferation and maturation. A new monoclonal antibody against BAFF-R was generated from a hybridoma clone and used to create a novel MC10029 CAR construct.