Hepatocyte FBXW7-Dependent Activity of Nutrient-Sensing Nuclear Receptors Controls Systemic Energy Homeostasis and NASH Progression in Male Mice

The authors revealed E3 ligase FBXW7 as a key factor regulating hepatic catabolism, stress responses, systemic energy homeostasis, and nonalcoholic steatohepatitis (NASH) pathogenesis with attenuated FBXW7 expression as a feature of advanced NASH.