In Vitro Evaluation and In Vivo Efficacy Studies of a Liposomal Doxorubicin-Loaded Glycyrretinic Acid Formulation for the Treatment of Hepatocellular Carcinoma

Liver-targeting ligand glycyrrhetinic acid was conjugated to polyethylene glycol via Steglich reaction and incorporated in liposomes, which were then loaded with doxorubicin hydrochloride by pH gradient method.