NewslettersUmbilical & Placental Cell NewsNOTCH3 Signaling Controls Human Trophoblast Stem Cell Expansion and DifferentiationBy lbeveridge - November 8, 2023047Using trophoblast stem cells, trophoblast organoids and primary cytotrophoblasts of early pregnancy, researchers showed that autocrine NOTCH3 signaling controlled human placental expansion and differentiation.[Development]Abstract