Paired Box 6 Gene Delivery Preserves Beta Cells and Improves Islet Transplantation Efficacy

Scientists identified paired box 6 (PAX6) as a critical regulator of beta cell survival. Under diabetic conditions, the human beta cell line EndoC-βH1, db/db mouse, and human islets displayed dampened insulin and incretin signalings and reduced beta cell survival, which were alleviated by PAX6 overexpression.