The Role of an Amphiphilic Helix and Transmembrane Region in the Efficient Acylation of the M2 Protein from Influenza Virus

The M2 protein of the influenza virus, which is acylated at a membrane-near amphiphilic helix serves as a model for studying the intricate signals governing acylation and its interaction with the cognate enzyme, DHHC20, was investigated using both experimental and computational assays.