METTL3-Mediated m6A Methylation Controls Pancreatic Bipotent Progenitor Fate and Islet Formation

The authors generated transgenic mice lacking RNA methyltransferase-like 3 (Mettl3) specifically in Pdx1+ pancreatic progenitor cells and found the mutant mice developed hyperglycemia and hypo-insulinemia at two weeks of age.