The Effect of Lactate Dehydrogenase Inhibitors on Proliferation, Motility and Invasion of Breast Cancer Cells In Vitro Highlights a New Role for Lactate

Researchers determined the use of pharmacological lactate dehydrogenase (LDH) inhibitors to reduce aggressive behavior of breast cancer cells. The effect of LDH inhibitors was investigated in both estrogen receptor (ER)+ and ER‑ breast cancer cell lines and in normal breast epithelial cells.