STAT3 Palmitoylation Initiates a Positive Feedback Loop That Promotes the Malignancy of Hepatocellular Carcinoma Cells in Mice

Researchers investigated the consequences of S-palmitoylation of signal transducer and activator of transcription 3 (STAT3) in HCC. In HepG2 cells in vitro, DHHC7-mediated palmitoylation enhanced the expression of STAT3 target genes, including HIF1A.