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LPA5-Dependent Signaling Regulates Regeneration of the Intestinal Epithelium Following Irradiation

The effects of lysophosphatidic acid (LPA)5 on intestinal stem cells were corroborated by studies using organoids derived from Lgr5-lineage tracking reporter mice with deletion of Lpar5 in Lgr5+-stem cells. [American Journal Of...

Combination of Bazedoxifene with Chemotherapy and SMAC-Mimetics for the Treatment of Colorectal Cancer

Researchers provided evidence that bazedoxifene inhibited tumour growth via direct interaction with the gp130 receptor to suppress IL-6 and IL-11-mediated STAT3 signalling. Additionally, bazedoxifene combined with chemotherapy synergistically reduced cell proliferation...

Inflammation and Cytomegalovirus Viremia during Pregnancy Drive Sex-Differentiated Differences in Mortality and Immune Development in HIV-Exposed Infants

[Nature Communications] In a secondary analysis of the SHINE trial in rural Zimbabwe researchers explored biological pathways underlying infant mortality, and maternal factors shaping immune development in HIV-exposed uninfected infants.

Overcoming BRAF and CDK4/6 Inhibitor Resistance by Inhibiting MAP3K3-Dependent Protection Against YAP Lysosomal Degradation

[Experimental & Molecular Medicine] Researchers identified MAP3K3 as a target for overcoming anticancer drug resistance. Depletion of MAP3K3 led to a substantial reduction in the yes-associated protein (YAP) protein level in melanoma and breast cancer cells.

FOXO1 Enhances CAR T Cell Stemness, Metabolic Fitness, and Efficacy

[Nature] Investigators showed that overexpression of FOXO1 promoted a stem-like phenotype in CAR T cells derived from either healthy human donors or patients, which correlated with improved mitochondrial fitness, persistence and therapeutic efficacy in vivo.

Living Artificial Skin: Photosensitizer and Cell Sandwiched Bacterial Cellulose for Chronic Wound Healing

[Advanced Materials] Inspired by the bio-functionality of natural skin, investigators bioengineered an artificial skin with bacterial cellulose sandwiched between photosensitizers and functionalized living cells. The artificial skin was non-toxic, biocompatible, and accelerated the healing process of infected diabetic wounds