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ICOS-expressing Regulatory T Cells Influence the Composition of Antitumor CTL Populations

[Proceedings of The National Academy of Sciences of The United States of America] Scientists investigated how insulin receptor (IR) signaling shaped kidney antibacterial defenses that prevent infection. Their primary outcome showed that deregulated IR signaling increases urinary tract infection susceptibility by inactivating essential integrated stress responses and immune pathways that prevent infection.

Metronomic Chemotherapy plus Anti-PD-1 in Metastatic Breast Cancer: A Bayesian Adaptive Randomized Phase II Trial

[Nature Medicine] Researchers performed a phase II clinical trial of metronomic chemotherapy combined with PD-1 blockade to compare the efficacy of combined conventional chemotherapy and PD-1 blockade using Bayesian adaptive randomization and efficacy monitoring.

BAG6 Restricts Pancreatic Cancer Progression by Suppressing the Release of IL33-Presenting Extracellular Vesicles and the Activation of Mast Cells

[Cellular & Molecular Immunology] Researchers used a Cre recombinase/LoxP-based reporter system in combination with single-cell RNA sequencing to monitor in vivo extracellular vesicle uptake and tumor microenvironment changes in mouse models for PDAC in a Bag6 pro- or deficient background.

Neonatal Cardiac Mesenchymal Stromal Cells Promote Recovery of Infarcted Myocardium through CD44 Mediated FoxP3+ T-Regulatory Cells after Vascular Infusion

Systemic injection of neonatal mesenchymal stromal cells stimulated immunomodulatory responses specifically by increasing FoxP3+ T-regulatory cell-influenced anti-inflammatory macrophages in heart. [Stem Cell Reviews and Reports] Full ArticleGraphical Abstract

Dendritic Cell–Based Immunotherapy in Patients With Resected Pancreatic Cancer

[Journal of Clinical Oncology] The US FDA approved eflornithine to reduce the risk of relapse in adult and pediatric patients with high-risk neuroblastoma who have demonstrated at least a partial response to prior multiagent, multimodality therapy including anti-GD2 immunotherapy.

Self-Assembling Peptides Induced by Eyes Absent Enzyme to Boost the Efficacy of Doxorubicin Therapy in Drug-Resistant Breast Cancer Cells

[Heliyon] Scientist studied the self-assembly of a short peptide and its fluorescence analogue induced by eyes absent (EYA) tyrosine phosphatases to boost the efficacy of doxorubicin (DOX) therapy in drug-resistant types of breast cancer cells,