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The authors showed that aberrant WNT signaling undermines extravillous trophoblast (EVT) cell differentiation. Notum, palmitoleoyl-protein carboxylesterase (NOTUM), a negative regulator of canonical WNT signaling, was prominently expressed in first-trimester EVT cells...

The authors described a sensitive analytical technique for tumor monitoring of Ewing sarcoma by detecting circulating extracellular vesicles secreted from Ewing sarcoma cells. Full Article

Lung fibrosis was induced using bleomycin in C57BL/6 mice. Cellular senescence was measured by immunofluorescence. Full Article

Researchers analyzed 205 patient samples to explore the relationships between tumor-stroma ratio and clinicopathological features. Full ArticleGraphical Abstract

Scientists engineered highly functional myovascular tissues that enabled studies of the roles of endothelial cell-satellite cell crosstalk in human muscle development, physiology, and disease. [Acta Biomaterialia] AbstractGraphical Abstract

Researchers elucidated the potential mechanism of inflammation and vascular smooth muscle cell phenotypic switch in β-aminopropionitrile fumarate-induced thoracic aortic dissection. [Molecular Medicine] Full Article