publication

Researchers demonstrated the feasibility of incorporating multisector sampling in cancer vaccine design and provided information on the clinical applicability of clonality, distribution, and immunogenicity of the neoantigen landscape in glibolastoma patients. [Clinical...

The effects of lysophosphatidic acid (LPA)5 on intestinal stem cells were corroborated by studies using organoids derived from Lgr5-lineage tracking reporter mice with deletion of Lpar5 in Lgr5+-stem cells. [American Journal Of...

Researchers provided evidence that bazedoxifene inhibited tumour growth via direct interaction with the gp130 receptor to suppress IL-6 and IL-11-mediated STAT3 signalling. Additionally, bazedoxifene combined with chemotherapy synergistically reduced cell proliferation...

[Nature Communications] In a secondary analysis of the SHINE trial in rural Zimbabwe researchers explored biological pathways underlying infant mortality, and maternal factors shaping immune development in HIV-exposed uninfected infants.

[Experimental & Molecular Medicine] Researchers identified MAP3K3 as a target for overcoming anticancer drug resistance. Depletion of MAP3K3 led to a substantial reduction in the yes-associated protein (YAP) protein level in melanoma and breast cancer cells.

[Nature] Investigators showed that overexpression of FOXO1 promoted a stem-like phenotype in CAR T cells derived from either healthy human donors or patients, which correlated with improved mitochondrial fitness, persistence and therapeutic efficacy in vivo.