Interferon Lambda Receptor-1 Isoforms Differentially Influence Gene Expression and HBV Replication in Stem Cell-Derived Hepatocytes

Induced pluripotent stem-cell-derived hepatocytes engineered to contain FLAG-tagged, doxycycline-inducible IFNLR1 isoform constructs were HBV-infected and then treated with IFNL3 followed by assessment of gene expression, HBV replication, and cellular viability.