Gp78 Deficiency in Hepatocytes Alleviates Hepatic Ischemia-Reperfusion Injury via Suppressing ACSL4-Mediated Ferroptosis

Hepatocyte-specific gp78 knockout or overexpressed mice were generated to examine the effect of gp78 on liver ischemia-reperfusion injury, and a multi-omics approach was performed to explore the potential mechanism.